Pharmacokinetics

Test Introduction

Diabetes is a group of diseases marked by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. The major source of blood glucose is dietary carbohydrates that are initially hydrolyzed by pancreatic α-amylase, followed by α-glucosidase before being absorbed in the small intestine. Reduction of the elevated postprandial blood glucose level is an established strategy for management of type 2 diabetes. Therefore, we provide 2 assay systems to prove the anti-hyperglycemia effect of your ingredients using "inhibition of carbohydrate hydrolyzing enzymes such as mammalian α-amylase and α-glucosidase" and "Postprandial anti-hyperglycemic assay in animal model system".

Sample

  • Plant
  • Fermented Broth
  • Bioconversion
  • Natural product

Analysis Process

  • In-vitro assay
  • In-vivo assay

Analysis Result

ORAC assay

2013.12.01

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Fluorescence (80nM) + + + + +
AAPH(80mM) + + + + +
국산 중국산
Sample (㎍/㎖) - 25 μg/ml 100 μg/ml 25 μg/ml 100 μg/ml
Test 19.86 24.76 47.60 24.38 48.07
20.94 26.32 51.03 25.97 49.77
20.11 25.01 48.51 25.48 48.02
Net area 4.23 27.07 3.85 27.55
20.53 5.80 30.51 5.44 29.25
4.48 27.98 4.96 27.49
Trolox(µM) 0.80 5.11 0.73 5.20
5.30 1.09 5.75 1.03 5.52
0.85 5.28 0.94 5.18
Mean 0.91 5.38 0.90 5.30
S.D 0.16 0.34 0.15 0.19