Pharmacokinetics
Functionality test
Inovative Technology Support Group for Life Science and Drug discovery
Test Introduction
Diabetes is a group of diseases marked by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. The major source of blood glucose is dietary carbohydrates that are initially hydrolyzed by pancreatic α-amylase, followed by α-glucosidase before being absorbed in the small intestine. Reduction of the elevated postprandial blood glucose level is an established strategy for management of type 2 diabetes. Therefore, we provide 2 assay systems to prove the anti-hyperglycemia effect of your ingredients using "inhibition of carbohydrate hydrolyzing enzymes such as mammalian α-amylase and α-glucosidase" and "Postprandial anti-hyperglycemic assay in animal model system".
Sample
- Plant
- Fermented Broth
- Bioconversion
- Natural product
Analysis Process
- In-vitro assay
- In-vivo assay
Analysis Result
ORAC assay
2013.12.01
Fluorescence (80nM) | + | + | + | + | + |
---|---|---|---|---|---|
AAPH(80mM) | + | + | + | + | + |
국산 | 중국산 | ||||
Sample (㎍/㎖) | - | 25 μg/ml | 100 μg/ml | 25 μg/ml | 100 μg/ml |
Test | 19.86 | 24.76 | 47.60 | 24.38 | 48.07 |
20.94 | 26.32 | 51.03 | 25.97 | 49.77 | |
20.11 | 25.01 | 48.51 | 25.48 | 48.02 | |
Net area | 4.23 | 27.07 | 3.85 | 27.55 | |
20.53 | 5.80 | 30.51 | 5.44 | 29.25 | |
4.48 | 27.98 | 4.96 | 27.49 | ||
Trolox(µM) | 0.80 | 5.11 | 0.73 | 5.20 | |
5.30 | 1.09 | 5.75 | 1.03 | 5.52 | |
0.85 | 5.28 | 0.94 | 5.18 | ||
Mean | 0.91 | 5.38 | 0.90 | 5.30 | |
S.D | 0.16 | 0.34 | 0.15 | 0.19 |
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