mRNA analysis
mRNA Analysis
Inovative Technology Support Group for Life Science and Drug discovery
LNPs analysis
Test Introduction
Lipid nanoparticles (LNPs) have emerged as promising delivery vehicles for nucleic acids in the pharmaceutical industry. To ensure safety and efficacy of the final drug product, the lipid components need analytical characterization of composition, ratio, and degradation.
Sample
- Raw mRNA pharmaceuticals
- Final mRNA pharmaceuticals
Analysis Process
- LNPs
- Standard and
sample preparation - LC-ELSD analysis
Analysis Result
Scroll to the left and right to reveal the contents.
| Peak | Lipid | Area % | LOD [pmol] |
LOQ [pmol] |
R² |
|---|---|---|---|---|---|
| 1 | Cholesterol | 27.25 | 8.4 | 28 | 0.99915 |
| 2 | DSPC | 27.35 | 2.6 | 7.7 | 0.99654 |
| 3 | DMG-PEG 2000 | 25.44 | 0.66 | 1.7 | 0.99987 |
| 4 | DLin-MC3-DMA | 19.96 | 5.31 | 17.1 | 0.99966 |