Protein analysis

Physicochemical Properties

Innovative Technology Support Group for Life Science and Drug Discovery

Extinction Coefficient(EC)
EC
Capillary Electrophoresis
DSC
Liquid chromatography(LC)
RP-HPLC

Capillary Electrophoresis : CE-SDS (capillary electrophoresis sodium dodecyl sulfate) 

Test Introduction

The mutation of a small amount of impurities in biopharmaceuticals is a common issue that occurs within the overall biomedicine pipeline, which would result in negative impacts in efficacy and stability. Thus, it is important to keep pace with the procedure through minimizing the time required for the pretreatment and processing of the sample. Making right decisions is possible based on the consistent quantitative analysis results from the CE-SDS technology that provides raw data with high reproducibility for obtaining approval by a regulatory authority.

Sample

  • Antibody
  • Antibody-drug conjugates
  • Recombinant protein
  • Toxine
  • Vaccine

Analysis Process

  • Sample pre-treatment
  • CE-SDS
  • M.W ID & Quantitative
    analysis

Analysis Result

Peaks

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Peak Name Time RMT MW(kDa) Height Raw Area Area %Total %Area Width S/N Baseline Resolution
1 Mkr 10 802.7 1.000 10 6.9 115.4 144.1 8.5 622.8 6.2
2 Mkr 20 938.0 1.169 20 8.2 187.1 200.1 15.1 11.1 743.3 7.8 7.55
3 Mkr 33 1046.2 1.303 33 8.0 197.2 188.6 14.3 11.6 722.4 7.9 6.48
4 Mkr 55 1212.3 1.510 55 10.8 269.8 222.5 16.8 11.8 973.8 10.8 8.84
5 Mkr 103 1444.8 1.800 103 7.6 224.0 154.6 11.7 13.3 682.2 6.8 14.44
6 Mkr 178 1651.8 2.058 178 3.6 277.0 167.5 12.7 33.9 321.3 3.5 4.85
7 Mkr 270 1877.8 2.340 270 4.2 733.2 389.7 29.5 87.6 375.0 4.1 2.30